The best tip I ever got (other than to use f.lux at all) was to set it to 5800K during the day. It's an almost unnoticeable difference, but makes a huge improvement in reducing my eyestrain.
I've found the lower the value the better for reducing eyestrain. Slowly lowering it down in about 100K chunks it doesn't take long to get used to each step. I currently have mine at 4900/4200 (day/night).
The night value hasn't bothered me so I haven't given it much thought. I set it to that value when I first started using it as lower just looked weird at that time. I should probably try lower values at night and see if it effects my sleep.
Setting it to 5700-5800 seems to have made a noticeable a big difference to me, as I'm plugging into my monitor at home right away my screen had less of a bite.