That's irrelevant. You're not going to "roll back" a brain replacement. Future technology does not allow arbitrary reversible manipulations of molecules. Creating new individuals is much less effort than rewriting old ones in any case.
But I'm not talking about brain replacements. Just regular technology. My point is that the evolution of collective human civilization is orders of magnitude faster than biological evolution of individual humans, making the latter irrelevant. The only "death" that happens in that faster evolution is loss of mindshare, these days most often seen as failure on the market.
You do not get to hand-wave away the fact of evolution, regardless of the level of technology. Populations change genetically over long periods of time, because math, and the idea that gene editing will not occur in the future (near or far) is not credible.
Magic does not exist, even in the future.