I agree that it's a killer experiment and someone should do it.
But BER doesn't sense double strand breaks. It senses changes in the curvature of the dna induced by point mutations that are solvable by extracting the base and replacing it templates by the other strand. So you'll want to induce damage with something that causes thymidine dimerization or DNA alkylation.
But BER doesn't sense double strand breaks. It senses changes in the curvature of the dna induced by point mutations that are solvable by extracting the base and replacing it templates by the other strand. So you'll want to induce damage with something that causes thymidine dimerization or DNA alkylation.