I have three children, and our solution was the Honda Odyssey. It has a separate back middle seat with its own pair of car seat anchors. Yes, it's big on the inside. None of the other SUVs I saw had the middle seat anchors.
I've been driving very small cars since I started driving. SUVs were rare and large pickups were usually only seen in rural areas. Today it seems as if everyone on the road has gone bigger and I feel very small in that car.
Whenever I'm stuck between several SUVs, often with the added disadvantage that the one behind me has its low beams on the same level as my rear view mirror, I can't say I feel safe.
If I were starting a family, I would definitely want a bigger car, even though I don't have any data indicating that it would be safer.