More generally, it is supremely uncomfortable inside some people's bodies. I don't just mean someone with physical pain. Anxiety, depression and other disorders are a whole-body experience.
I believe this is a wildly underappreciated fact: Most folks are miserable, and most of us don't realize it due to a kind of "fish don't notice water" effect.
> Under the present brutal and primitive conditions on this planet every person you meet should be regarded as one of the walking wounded. We have never seen a man or woman not slightly deranged by either anxiety or grief. We have never seen a totally sane human being.