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Researchers find a treatable indicator of blood clotting in Covid patients (virginia.edu)
66 points by geox on Dec 13, 2021 | hide | past | favorite | 16 comments


"Massive image-based single-cell profiling reveals high levels of circulating platelet aggregates in patients with COVID-19", doi:10.1038/s41467-021-27378-2, Open Access

https://www.nature.com/articles/s41467-021-27378-2


Is/has anyone tested or studied the affects of blood thinners on Covid?


The paper itself says that blood thinners are already recommended for Covid patients.

"In response to a number of reports that anticoagulant therapy with heparin leads to better prognosis in COVID-19 patients, both domestic and international organizations have issued clinical practice guidelines recommending that all hospitalized COVID-19 patients should receive thromboprophylaxis (mainly heparin treatment) even without clear symptoms of thrombotic complications and understanding their efficacy."


Yep - it was clear from the beginning that hospitalized patients throw a ton of clots, so it's been in the guidelines since 2020 to treat anyone presenting with Covid symptoms with prophylactic thinners;

> Hospitalized nonpregnant adults with COVID-19 should receive prophylactic dose anticoagulation (AIII) (see the recommendations for pregnant individuals below). Anticoagulant or antiplatelet therapy should not be used to prevent arterial thrombosis outside of the usual standard of care for patients without COVID-19 (AIII).

From what I understand, there doesn't seem to be much benefit for overall treatment of the disease (e.g. sick people's lungs don't get better more quickly) but it's preventing tons of PEs and strokes so that's obviously very valuable.

https://www.covid19treatmentguidelines.nih.gov/therapies/ant...


When I have been in hospital (UK) I was given heparin anyway this seems to be SOP for the NHS


I was thinking more like the affect of thinners already in use on a person (such as myself) if they get the rona, and how it affects disease progression.


Well I am on aspirin and when I got Covid in october (whilst in hospital for something else) my case was rather mild


Go see the links I posted upstream.


Yes. And here's one news report:

"Aspirin lowers risk of COVID: New findings support preliminary Israeli trial" [0]

[0]: https://www.jpost.com/health-and-wellness/aspirin-lowers-ris...


Oh, and here's from the original paper:

"...Moreover, the group observed that the conversion time of SARS-CoV-2 PCR test results from positive to negative among aspirin-using COVID-positive patients was significantly shorter, and the disease duration was two-three days shorter, depending upon the patients' pre-existing conditions."

[0]: https://www.biu.ac.il/en/news/8919


Aspirin is strongly associated with Reyes Syndrome in children with viral infections. Might not be a great idea at least for kids.


Blood thinners are not fun. Brain bleeds are a risk.


Blood clots shooting into the brain also are not fun.

Anti-platelets and blood thinners can help in that regard to prevent clotting in the first place.

Generally an aspirin a day will help more than hurt, consult your doctor ofc.


My cardio doc took me off the aspirin. Has me on eliquis after the afib post moderna vax.


Thats a Good News!


Platelet agglomeration and general weirdness has been known for about a year. I guess the new info is prevalence or quantity?




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