I agree with this: the game appears simple but there are some surprisingly complex interactions, and even pro players consult the wiki/spreadsheet/external resources during their runs. For example, only last month did Jorbs discover something new about how Gold-Plated Cables and Emotion Chip and Loop operate (something about how GPC fires earlier or later than Loop, which affects when you want to take damage during the Heart fight with Beat of Death going); on the last stream, he also ran into War Paint making Snecko Eye worse because it upgraded Dualcast to 0-cost, which means that the Apotheosis he had in his deck was unable to lower the cost of a e.g. 3-cost Dualcast+ (normally, Apothesois lowers a Snecko-randomized energy cost to the correct value when it upgrades a deck mid-fight). Keep in mind that this is someone who has >8000 hours put into this game, and these discoveries are still causing him to update his priors.

Great game! Every decision matters!