Much like Clojure is lisp on the Java virtual machine, Hy is a lisp on Python. There are definitely plenty of ways in which lisps vary and I've heard Hy tends to follow some Pythonisms more closely than other lisps may follow their host languages.
Hy (or “Hylang”) is a multi-paradigm general-purpose programming language in the Lisp family. It’s implemented as a kind of alternative syntax for Python. Hy provides direct access to Python’s built-ins and third-party Python libraries, while allowing you to freely mix imperative, functional, and object-oriented styles of programming.