IMO the fact that being a full-stack dev is so taxing is an indication that the stack as a whole is just way too complex and overengineered. Which is rather obvious from looking at the state of affairs on the frontend side of things. Desktop GUI devs don't usually have those problems.
Thing is, even when web apps are essentially used as desktop app replacement (Electron etc), all the complexity discussed here is still there.
As far as looking OS-native, this is (unfortunately) increasingly less relevant as OSes themselves drop desktop UX consistency even internally. But that aside, Qt is still around and is a very mature framework for "near native" UI, and then there's Avalonia and others. Even Gtk is surprisingly decent on Windows these days. Although I'm not sure what this all has to do with the original subject, since web apps most certainly don't look native anywhere.
