Yes, Jumbo frames unlock a LOT of additional performance - which is exactly what we have and need on those links. Using a vanilla wg-bench[0] loopback-esque (really veths across network namespaces) setup on the machine, I get slightly more than 15Gbps sustained throughput.
25G is a lot for WireGuard [1].
1. https://www.youtube.com/watch?v=oXhNVj80Z8A