Sure. Say you're a bright young Harvard business school graduate. You might choose to either found a start-up, or go to a VC firm and help fund start-ups. The latter path is much lower risk (because you're not risking your own money, but rather that of the limited partners), but statistically you'll also probably come out ahead, financially, going that route.
Or to pose another example, starting a restaurant is probably riskier than starting a B2B software company, but also probably much less financially rewarding.
But both paths come with risk. Riskier doesn't always mean more reward, but no risk at all does mean no reward. That's all I really meant. Risk is of course relevant to each of us and we all define it differently, but everyone entertains some form of risk in their lives in order to just eat and keep a roof over our heads. It's worth it :D
Or to pose another example, starting a restaurant is probably riskier than starting a B2B software company, but also probably much less financially rewarding.