The plutonium shortage in NASA really has nothing to do with technology or science, but just politics. We simply stopped producing the stuff, but we could start again at any time; as the article you linked mentions, we're planning on doing so.
"For the first time in 25 years, the United States is producing plutonium fuel to power spacecraft on missions beyond Earth, replenishing a dwindling stockpile to supply NASA's next Mars rover and other proposed probes."
That's like saying we won't run out of oil because we are producing carbon and oxygen... if it's not in useful form, it's perfectly sensible to say that no new fuel is being produced.
Normal uranium reactors produce a mix of plutonium isotopes, which are hard to separate and end up as nuclear waste. NASA needs pure Pu-238, which has to be made in specialized reactors.
http://www.isciencetimes.com/articles/6087/20130919/nasa-plu...